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Publication: Diabetes Update
The Numer One Priority

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Diabetic Digest - Wednesday, June 20, 2007
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News, updates and help from and for the diabetic community.
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Readers:

A week ago I had an appointment to visit my doctor. Every-
thing went well and I received my results for the A1C 
blood test a few days later. My blood-sugar average (for 
the passed three months) was 129 and my A1C reading was a 
5.8... which is perfect. 

I don't mean to toot my own horn, but my health is my 
number one priority. I get nervous when it comes time for 
me to pay my doctor a visit. So many problems occur with 
those that have diabetes and don't take care of themselves. 
I just want to avoid any problems or complications with 
this manageable illness. I want to enjoy all that I can 
without the burdon of illness. 

I take care of myself and that leaves me more time than I 
know what to do with. I guess what I'm trying to say is... 
take care of yourself and your time will be filled with 
those things that make life worth living. 

Have a great day. 

Regards,
Steve

Diabetic Update Newsletter 
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Diabetes Drug May Help Obese People Eat Less

NEW YORK (Reuters Health) - Obese subjects ate nearly 1,000 
fewer calories per day when they injected pramlintide, a 
drug approved for the treatment of insulin-dependent 
diabetes, before every meal, a new study shows. 

The subjects were also less likely to binge eat and ate 
less when faced with "fast-food challenges" of deep-dish 
pizza, sugary sodas and ice cream. 

Pramlintide is a synthetic version of the human hormone 
amylin, which is secreted by the pancreas along with 
insulin after meals. Amylin is referred to as a "satiety" 
hormone, meaning it signals a feeling of fullness to let 
the body know it is time to stop eating.

San Diego-based Amylin Pharmaceuticals makes pramlintide, 
which is sold under the trade name Symlin. In previous 
studies, the company demonstrated that people taking Symlin 
for 1 year lost 8 percent of their body weight. The current 
study was designed to evaluate how the drug contributes to 
weight loss.

Dr. Christian Weyer of Amylin and his colleagues randomly 
assigned 88 obese subjects self-injection with pramlintide 
or placebo before each meal for 6 weeks. During the course 
of the study, participants underwent three "fast-food 
challenges."

By the third day of the study, the subjects on pramlintide 
were consuming about 750 fewer calories a day than those on
placebo and 990 calories a day less than before they began 
taking the drug. At day 43, those on pramlintide were 
eating about 500 fewer calories than those on placebo.

While the pramlintide-placebo calorie intake difference 
shrank as the patients on the drug lost weight, it remained
"robust," the researchers note, which is "noteworthy" given 
that people typically start feeling hungrier after they 
lose a significant amount of weight.

The subjects on pramlintide also ate smaller portions and 
consumed less during the fast food challenges. The 
pramlintide group ate 385 fewer calories on the challenge 
at 44 days compared with the initial challenge on day 2, 
while the corresponding number for the placebo group was 
109 fewer calories.

By day 44, the pramlintide group lost an average of 2 
percent of their total body weight, compared with an 
average gain of 0.11 percent for those on placebo.

While peptide hormones like pramlintide have been shown to 
induce nausea, Weyer and his team point out, they used a 
low dose in the current study, and study participants 
taking the drug were not significantly more likely to feel 
nauseous than those on placebo.

Weyer told Reuters Health that his group is now evaluating 
a combination of pramlintide and leptin -- another satiety
hormone -- or treating obesity. Studies in animals have 
found the combination produces a stronger effect than 
either hormone alone. The researcher said results of human 
studies of the hormone combination are expected this year.

SOURCE: American Journal of Physiology, Endocrinology and 
Metabolism, July 2007.

Copyright 2007 Reuters Limited.

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                    Diabetic Recipe

                Roasted Red Pepper Dip

(makes about 2 1/2 cups, 600 ml)

2 large red bell peppers, about 1 pound (480 g) total
1 large red onion, 8 ounces (240 g), peeled and sliced
2 large garlic cloves, peeled
1 cup (240 ml) plain nonfat yogurt
2 tablespoons (30 ml) minced fresh parsley
1/4 teaspoon (1.25 ml) hot pepper sauce
salt (optional) and freshly ground pepper to taste

1. Preheat the broiler. Cut peppers in half lengthwise, 
   discarding seeds and membranes. Place the peppers, 
   cut side down, on a foil-lined baking sheet. 

2. Surround with onion and garlic. Broil for 10 minutes or 
   until peppers are blackened. Immediately place peppers 
   in self-sealing plastic bag. Seal and let stand for 
   15 minutes. Rinse peppers under running cold water, 
   slipping off the peel.

3. Place peeled peppers, onion, and garlic in a food 
   process or blender. Process until finely chopped. 
   Transfer mixture to a bowl and fold in remaining 
   ingredients. Cover and chill until ready to serve. 
   (May be made the day before.) 

Per 2-tablespoon (30 ml) serving: 19 calories (4% calories 
from fat), 1 g protein, trace total fat (0 saturated fat), 
4 g carbohydrate, 1 g dietary fiber, trace cholesterol, 
10 mg sodium

Exchanges: free (for 2-tablespoon portion; if eating more, 
it becomes 1 vegetable) 

Copyright Diabetic-Lifestyle 

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          GopherCentral's Question of the Week

Should Illegal Aliens receive government subsidized health
benefits in the US?

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Copyright 2007 by NextEra Media. All rights reserved.

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