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Publication: Diabetes Update
Halloween Fun

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Diabetic Digest - Wednesday, October 24, 2007
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News, updates and help from and for the diabetic community.
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Readers:

Halloween is only a week away and for kids with diabetes 
this used to mean trouble. 

When I was diagnosed at the age of 9, I was devastated 
when Halloween came around. It was the only time of year 
that I ever ate candy (I wasn't a big candy person). I 
still dressed in costume and went house to house with 
my brother to get him more candy, but I got to keep 
the pennies and dimes the old ladies would give us. 

As I went to a neighbor's house to trick-or-treat I 
discovered they had gone out and bought some sugar free 
candy just for me. Diabetes was still new to my family
and I and we had no idea that sugar free candy was
available. It was the greatest feeling to be able to
enjoy Halloween and trick-or-treating like in the past.

Today, kids with diabetes can enjoy candy on Halloween 
just the same. I recently went to pick myself up some 
sugar free candy and I just can't believe the variety 
of candy specifically for diabetics. You just have to 
remember that you can only enjoy a small amount at a 
time or else you'll have to spend the majority of All 
Saints' Day in the bathroom. (I learned the hard way). 

Halloween is just as fun as it ever was and I'm glad. 
We all know what a little treat can do for your spirits. 

Regards,
Steve

Diabetic Update Newsletter 
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         Inhaled Insulin Exubera Discontinued

NEW YORK (Reuters) - Exubera, an inhaled insulin product
for diabetes, has been withdrawn from the market by Pfizer
Inc, which is taking a $2.8 billion charge to end its
involvement with the poorly selling drug, leading to a
sharp fall in third-quarter earnings, the company said
Thursday.

Deutsche Bank analyst Barbara Ryan said Pfizer's abandon-
ment of Exubera, with revenues so far this year of only
$12 million, was irrelevant from a financial perspective.

"They tested the patient (Exubera) and there was no pulse,
so it's going from zero to zero," she said.

Exubera, designed for the treatment of diabetes type
1 or 2 had, "simply not found the acceptance of doctors and
patients," Chief Executive Jeff Kindler told analysts on a
conference call.

"We will carefully evaluate what happened here," Kindler
said, referring to the unpopularity of the product. More-
over, he said Pfizer will halt further research on second-
generation forms of inhaled insulin.

Exubera, developed in partnership with Nektar Therapeutics,
was approved by U.S. regulators in January 2006 and made
history as the first form of inhaled insulin. Other
companies are trying to develop similar products.

New York-based Pfizer said it would return its worldwide
Exubera rights to Nektar, and work with doctors over the
next three months to switch Exubera patients to other
diabetes treatments.

After being launched, many investors assumed Exubera would
become a sure-fire blockbuster on the theory that diabetics
would prefer an inhaled form of insulin over traditional
injectable forms of the hormone used to control blood
sugar.

Instead, Exubera became a dud, with paltry sales. Some
analysts speculated the bulky canister device used to
administer the powdered drug was a problem for patients.

Copyright 2006 Reuters Limited. All rights reserved.

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   Company Denies New Diabetes Drug Causes Pancreatitis

COPENHAGEN (Reuters) - No increased risk of acute 
pancreatitis has been observed so far in clinical trials 
of the diabetes type 2 drug liraglutide, which is in late-
stage clinical trials, Denmark's Novo Nordisk, the world's 
biggest maker of insulin, said on Wednesday. 

The U.S. Food and Drug Administration (FDA) warned doctors 
and patients on Tuesday that Amylin Pharmaceuticals Inc's 
and Eli Lilly and Co's diabetes drug Byetta may be linked 
to acute pancreatitis in some patients. 

Novo Chief Science Officer Mads Krogsgaard told Reuters 
that tests on over 3,000 patients had showed no signs of 
acute pancreatitis with liraglutide compared with placebo. 

"Type 2 (diabetes) patients and obese people have an 
increased risk of getting pancreatitis from the outset. 
So in relation to the placebo group we have not seen signs 
that liraglutide causes pancreatitis," he said. 

Byetta and liraglutide are both members of a new class of 
medications to treat type 2 diabetes. 

Byetta, which is known generically as exenatide, was 
launched in the United States in mid-2005 as the first 
drug in its class. Its success has been due in part to the 
drug's ability to help patients shed weight. 

The drug is a synthetic version of a hormone in the saliva 
of the Gila monster lizard. Liraglutide is a genetically 
modified version of the human hormone GLP-1, which 
stimulates insulin production. 

Krogsgaard said it was still too early to say if the 
increased risk of pancreatitis was specific to Byetta or 
if the entire class of drugs would have the same side 
effects. 

"The Byetta effect could be specific for Byetta because 
it comes from this lizard, the Gila monster, and is 
different from human GLP1. Or it could be a class effect 
that will be noted for all GLP1's, ours and theirs." 

Krogsgaard said Novo hopes to received regulatory approval 
for liraglutide in Europe and the U.S.by mid-2008. 

Copyright 2006 Reuters Limited. All rights reserved. 

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                     Diabetic Recipe

                      Witch's Brew

                   (makes 16 servings)

dry ice

2 .32-ounce (9 g) sugar-free grape or black cherry drink mix

cold water

1 46-ounce (1.4 l) can unsweetened pineapple juice, chilled 

1 quart (1 liter) sugar-free lime-flavored carbonated 
beverage or sugar-free ginger ale, chilled

1. Place a punch bowl into a larger bowl so that you have 
   a gap of at least 3 inches between the two bowls. Fill 
   the gap with small pieces of dry ice. 

2. Reconstitute drink mix with cold water according to 
   package directions, stirring until dissolved. Pour 
   into a punch bowl and stir in cold pineapple juice. 

3. Slowly add carbonated beverage and serve. 

Per 1-cup serving: 51 calories (0% calories from fat), 
                   trace protein, 0 total fat (0 saturated 
                   fat), 11 g carbohydrate, 0 dietary 
                   fiber, 0 cholesterol, 3 mg sodium 

Diabetic exchanges: 1 carbohydrate (fruit) 

Copyright 1997-2001 Diabetic-Lifestyle. 

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End of DIABETIC DIGEST
Copyright 2007 by NextEra Media. All rights reserved.

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