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Publication: Diabetes Update
A Little Fresh Air

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Diabetic Digest - Wednesday, April 9, 2008
News, updates and help from and for the diabetic community.


It looks as if Spring has finally sprung. That's good 
news for those of us that have been couped up in-doors 
all winter long yearning for finer weather that will help 
to motivate us to experience some worthwhile exercise and 
fresh air. I know I need some fresh air... and exercise. 

Sunshine and fresh air are great motivators when it comes 
to outdoor activities. I think I'm going to put my winter 
coat away and take a nice long walk to wake up my muscles 
and get them ready for a long Summer that's sure to be 
filled with plenty of things to get me into healthier 

A little fresh air and exercise will be good for all of 


Diabetic Update Newsletter 
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Exercise Boosts Peripheral Insulin Sensitivity Diabetics

NEW YORK (Reuters Health) - The improvement in whole-body
insulin sensitivity seen in type 2 diabetics who engage
in aerobic exercise is due to gains in insulin sensitivity
that occur in extremities, not in the liver, study findings

Dr. Jason J. Winnick from the Department of Molecular
Physiology at Vanderbilt University Medical Center,
Nashville, Tennessee, and colleagues at Ohio State
University, Columbus, determined the effect of 7 days of
aerobic exercise training on insulin sensitivity in the
extremities and insulin sensitivity in the liver for 18
obese adults with type 2 diabetes.

As reported in the Journal of Clinical Endocrinology and
Metabolism, all study subjects discontinued their diabetes
medications and maintained a balanced diet consisting of
50 percent carbohydrate, 30 percent fat, and 20 percent
protein for 15 days.

During the second week, 9 randomly selected subjects also
walked on a treadmill for 50 minutes daily at 70 percent
of maximum oxygen consumption. Each subject underwent
initial measurements of glucose and insulin levels after
the first week of the diet and second measurements clamp
after completing the second week.

Winnick told Reuters Health, "In response to our 1-week
exercise training protocol that involved moderate intensity
walking, there was a fairly large increase in insulin's
ability to stimulate glucose uptake by the whole body
(i.e., whole-body insulin sensitivity) and muscle (i.e.,
muscle insulin sensitivity)."

"However, within the same time frame," he continued,
"exercise training did not improve insulin's ability to
stimulate decreases in liver glucose production."

It is likely, the researcher added, that without
restricting calories, it takes more than a week to
improve insulin sensitivity in the liver among those
with diabetes.

It is also worth noting, Winnick said, that, despite
discontinuation of diabetes medications, the fasting
blood glucose values did not change over the intervention
period -- so glucose metabolism can improve within one
week of starting an exercise program.

"In particular, blood glucose after a meal may be improved
due to improved muscle glucose uptake, despite not showing
a change in the fasting blood glucose level," Winnick

SOURCE: Journal of Clinical Endocrinology and Metabolism,
March 2008.

Copyright 2006 Reuters Limited. All rights reserved.


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         Diet Drug Misses Mark in Diabetes Study

CHICAGO (Reuters) - The Sanofi-Aventis SA weight loss drug
rimonabant failed to slow heart disease by a key measure
in obese patients with fat around the middle, and it
significantly increased the risk of anxiety and depression,
U.S. researchers said on Tuesday.

They said more than 40 percent of patients who took the
drug, sold as Acomplia in Europe, developed psychiatric

However, patients who got the drug did show signs of
improvement in a secondary measurement of coronary artery
disease, suggesting the drug should be studied further,
according to the study, which was presented at the American
College of Cardiology meeting in Chicago.

The drug, known generically as rimonabant, is not approved
for sale in the United States after a U.S. expert panel
last year recommended against its approval because of
concerns over psychiatric risks.

While the drug helped reduce abdominal fat and improved
blood work, it failed to meet the study's main goal of
reducing the Percent Atheroma Volume -- a measure of
plaque in a cross-section of the arteries. It did,
however, reduce the Total Atheroma Volume -- a measurement
of the total amount of plaque in the coronary artery.

Copyright 2006 Reuters Limited. All rights reserved.

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                     Diabetic Recipe

                    Pineapple Squares

                    (makes 25 squares)

oil and flour aerosol spray
3/4 cup (299) juice-packed canned pineapple chunks, drained
1 large egg
1/2 cup (80 ml) unsweetened pineapple juice
1/4 teaspoon (1.25 ml ) orange extract
1 tablespoon ( 15 ml) vegetable oil
1 1/2 cups (211 g) flour
1 teaspoon (5 ml) baking soda
1 teaspoon (5 ml) baking powder

1. Preheat oven to 350°F (180° C, Gas Mark 4). Spray an 
   8-inch (20 cm) square baking pan with aerosol spray. 

2. Measure out 1/4 cup (100 g) of the pineapple chunks. 
   Puree until smooth in a food processor or blender. In 
   the bowl of an electric mixer, beat together pureed 
   pineapple, egg, pineapple juice, orange extract, and 
   oil. Add the flour, baking soda and powder and beat 
   again Stir in the remaining 1/2 cup (199 g) pineapple 

3. Spoon the batter into the prepared pan. Smooth the top 
   and bake for 25 minutes until a knife inserted in the 
   middle comes out clean. Cool and cut into 25 squares. 

Per 2 squares: 82 calories (19% calories from fat), 
               2 g protein, 1 g total fat (0.2 g saturated 
               fat), 14 g carbohydrate, trace dietary 
               fiber, 18 mg cholesterol, 146 mg sodium 

Diabetic exchanges: 1 carbohydrate (bread/starch) 

Copyright 1997-2001 Diabetic-Lifestyle. 


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