Publication: Health Tips Weekly New liver cancer treatment is studied | |
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HEALTH TIPS WEEKLY - Thursday, February 14, 2008
"News That Keeps You Healthy"
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Urine proteins: coronary disease markers
GLASGOW, Scotland, -- A Scottish research team has determ-
ined a set of 15 proteins found in urine can be used as bio-
markers for coronary artery disease. The University of
Glasgow scientists said that since urine samples are easily
obtained, urinary protein analysis is emerging as a powerful
tool to detect and monitor disease. Anna Dominiczak and col-
leagues tested whether urine could provide useful biomarkers
for coronary disease, one of the leading worldwide killers.
They analyzed samples from 88 CAD patients and 282 controls
and found a 15 protein "signature" indicative of disease.
Several of the protein fragments were collagens, which are
components of arterial walls. The researchers next examined
how predictive their protein panel was and found it could
identify the presence of CAD 83 percent of the time. The
panel had a sensitivity of more than 98 percent. The medical
scientists also observed the protein signatures of CAD ind-
ividuals became more normal after exercise, suggesting the
biomarkers can be used to both help diagnose CAD and monitor
the progress of treatment. The study is published in the
February issue of the journal Molecular and Cellular
Proteomics.
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Potent anti-cancer drug found in algae
SAN DIEGO, -- U.S. scientists have identified a potent,
anti-cancer drug isolated from an algae found in the
South Pacific. A University of California-San Diego
team of researchers led by Dr. Dennis Carson, a professor
of medicine and director of the university's Moores Cancer
Center, said the drug somocystinamide A, or ScA, was iso-
lated from a toxic blue-green algae. "We are excited because
we have discovered a structurally unique and highly potent
cancer-fighting compound," said Associate Professor Dwayne
Stupack. "We envision it will be perfect for emerging tech-
nology, particularly nanotechnology, which is being devel-
oped to target cancerous tumors without toxic side effects."
The ScA compound was found in the cyanobacteria L. Majus-
cula, also known as "mermaid's hair," gathered off the coast
of Fiji in the South Pacific by researchers at the Scripps
Institution of Oceanography. The scientists found ScA in-
hibits neovascularization, the formation of blood vessels
that feed tumors, and also had a direct impact on tumor cell
proliferation. The research is reported in the online early
edition of the Proceedings of the National Academy of Sci-
ence.
New liver cancer treatment is studied
PHILADELPHIA, -- U.S. medical scientists have started an
18-month study of a new liver cancer treatment that in-
volves the use of millions of tiny, radioactive beads.
The Thomas Jefferson University Hospital researchers
said the technique, called radioembolization, is being used
for the first time in patients with hepatocellular carci-
noma, or primary liver cancer. Dr. Brian Carr, an oncology
professor at the university's medical college, said the
trial also includes patients from the University of Texas'
M.D. Anderson Cancer Center in Houston and the University of
Pittsburgh. Carr said the tiny beads, or "microspheres,"
containing the radioactive isotope Yttrium-90 are injected
into the liver's hepatic artery. The microspheres, in add-
ition to blocking blood flow to the tumor, emit radiation
directly to the cancer, sparing healthy tissue. Although the
treatment doesn't cure the cancer, it can shrink tumors and
help patients live longer. "Ideally, if the radioemboli-
zation trial is successful, many of these patients would
have their liver tumors shrunken to the point where surgery
is possible," said Carr. "It would be a significant contri-
bution to the field if we could downstage the tumors so we
could do more transplants, which is the only cure."
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Gene chips ID ventilator-linked pneumonia
ST. LOUIS, -- U.S. scientists have used gene chip tech-
nology to identify hard-to-diagnose ventilator-linked cases
of pneumonia. Critically ill patients sometimes require the
use of mechanical ventilators, but then face a high risk of
pneumonia. Such lung infections, said the researchers, are
difficult to diagnose because a patient's underlying cond-
ition often skews laboratory test results. In the new res-
earch, scientists at Washington University in St. Louis
used gene chip technology to demonstrate for the first
time they can distinguish ventilator-linked pneumonia from
other serious illnesses. The team analyzed patterns of ex-
pression in more than 8,000 genes as patients on mechanical
ventilators developed and recovered from pneumonia. They
found changes in 85 genes could be used to pinpoint early
activation of the immune system in response to pneumonia.
"This is an important step toward the development of a spec-
ific molecular test for diagnosing infection … and predic-
ting patients' recovery," said Dr. J. Perren Cobb. "If we
could determine which patients are destined to develop
pneumonia based on early changes in the activity of genes …
we could give them antibiotics sooner, with the hope we
might be able to prevent or curtail the infection." The
research appears in the online journal PLoS One.
Measles spread on Hawaiian Airlines flight
SAN DIEGO, -- Health officials are trying to find about 250
people who may have been exposed to measles on a flight from
California to Hawaii. The San Diego Union-Tribune said Haw-
aiian Airlines flight 15 from San Diego to Hawaii last Sat-
urday included a infant who contracted the illness in a San
Diego medical clinic. The child is being treated on a mil-
itary base in Hawaii. Dr. Wilma Wooten, San Diego County's
public health officer, said officials are most concerned
about children who have not been immunized. The outbreak
began when a 7-year-old returned to San Diego from a family
vacation in Switzerland Jan. 15 infected with measles, the
newspaper said. The 7-year-old set off a chain reaction that
has infected two siblings and at least one classmate. San
Diego County health officials said they've confirmed measles
in five patients and investigating five suspected cases.
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Scientists learn how iron harms the brain
COVENTRY, England, -- British and Indian scientists have
found how iron accumulates in the brain, resulting in some
forms of Parkinson's, Alzheimer's and Huntington's diseases.
Although essential to human health, iron can be toxic. The
body employs a protein called transferrin to transport iron
safely through the bloodstream to tissues in which it can be
used. The protein combines molecules of iron with another
substance and then curls around the iron to seal it, prev-
enting any interactions until the iron reaches tissues in
which it can be used. The researchers discovered that when
this mechanism did not work properly, molecules of transfer-
rin arranged themselves into filaments. Instead of being
safely enclosed by the transferrin, iron was deposited along
the length of the filaments in a series of spots or bands.
When transported in that manner, iron was dangerously exp-
osed, and could interact in ways that damage cells. The
researchers said they believe their findings will help in
understanding how forms of Parkinson's, Huntington's and
Alzheimer's occur, and how they can be treated. The study,
which involved scientists from the University of Warwick
and the Indian Institute of Technology, appears in the on-
line edition of the journal Angewandte Chemie.
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