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Sperm cells provide cancer clues | |
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HEALTH TIPS WEEKLY - Thursday, December 27, 2007
"News That Keeps You Healthy"
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FDA orders new Nonoxynol-9 warning
WASHINGTON, -- The U.S. Food and Drug Administration issued
a final rule Tuesday requiring manufacturers of nonoxynol-9,
or N9, to add a warning to the product's label. The FDA said
the warning must state the over-the-counter vaginal contrac-
eptive and spermicidal product does not protect against in-
fection by the human immunodeficiency virus that causes
AIDS, nor does it protect against other sexually transmitted
diseases. Stand-alone spermicides include gels, foams,
films, or inserts containing N9 that are used by themselves
for contraception. The federal agency said consumers can
protect themselves from the transmission of STDs and HIV by
practicing abstinence, being in a monogamous relationship
with an uninfected partner and by using condoms consistently
and correctly. The FDA said it issued the rule to correct
misconceptions that the chemical N9 protects against sex-
ually transmitted diseases, including HIV infection. In add-
ition, the FDA is requiring the labels warn consumers that
N9 in stand-alone vaginal contraceptives and spermicides can
irritate the vagina and rectum, which may increase the risk
of contracting HIV/AIDS from an infected partner.
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Study shows how dioxin disrupts cells
PHILADELPHIA, -- U.S. scientists have determined the process
by which the chemical dioxin attacks the body's cells and
promotes tumor growth. University of Pennsylvania School of
Veterinary Medicine researchers determined that mitochondria
-- the cellular sub-units that convert oxygen and nutrients
into cellular fuel -- are targeted by tetrachlorodibenzodi-
oxin, or TCDD, the most toxic compound in the dioxin family.
The study showed TCDD induces mitochondria-to-nucleus stress
signaling, which in turn induces the expression of cell nuc-
leus genes associated with tumor promotion and metastasis.
The scientists said their findings are directly relevant to
understanding cancers in human populations exposed to such
chemicals. "Now that we have identified this signaling mech-
anism, we can look at ways to disrupt this complex chain of
events," said Narayah Avadhani, the study's lead investi-
gator. "Our ultimate goal is to block the propagation of
this mitochondrial stress signaling and inhibit the express-
ion of the proteins that combine to assist cancer growth."
Herceptin helps women with breast cancer
JACKSONVILLE, Fla., -- U.S. medical scientists determined
treatment with Herceptin helps women with a specific type
of breast cancer. Herceptin is a laboratory-manufactured
substance that shuts down a cancer-promoting protein called
HER2-plus, which accounts for approximately 20 percent of
all breast cancer cases. The HER2-plus protein is made by a
gene from chromosome number 17 and the study by researchers
at the Mayo Clinic in Jacksonville, Fla., showed Herceptin
was effective even in women with extra copies of that chro-
mosome. The research team, led by Dr. Edith Perez, found 865
patients with extra copies of chromosome 17, and 685 women
with the normal number -- two copies -- of chromosome 17
benefited equally with Herceptin. Their disease-free survi-
val was about 89 percent at both three years and five years.
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Alcohol hurts recovery from inflammation
LOS ANGELES, -- A U.S. study suggested that alcohol makes
rats vulnerable to, but doesn't directly cause, a chronic
inflammation of the pancreas known as pancreatitis. How-
ever, the team of Californian scientists found alcohol im-
pairs recovery from acute pancreatitis and sensitizes the
pancreas to chronic injury. They said their findings help
explain why only a small percentage of heavy drinkers deve-
lop chronic pancreatitis. The researchers from UCLA, the
University of Southern California, and the Department of
Veterans Affairs' Greater Los Angeles Healthcare System
found alcohol greatly sensitizes the pancreas to pathologic
responses of chronic pancreatitis. Some rats in the study
were given alcohol, plus high doses of a drug that induces
inflammation of the pancreas through excessive stimulation
of digestive secretions. Other rats were given the inflamma-
tion-inducing drug, but no alcohol. Rats given both alcohol
and the inflammation-inducing drug lost 86 percent of an im-
portant type of cells in their pancreas, while rats receiv-
ing only the inflammation-inducing drug showed no cell loss.
The researchers concluded alcohol harmed the capacity of the
rats to recover from the drug-induced inflammation.
Sperm cells provide cancer clues
LONDON, -- U.S. and British researchers say sugar-based
markers on sperm cells could provide a clue to how cancer
can spread in the human body,. The report, published online
in the Journal of Biological Chemistry, said the markers are
believed to tell the female immune system that the sperm are
not dangerous pathogens and should not be attacked by the
woman's white blood cells during the reproductive process.
Researchers from Imperial College London and the University
of Missouri said the marker also is found on some types of
cancer cells, some bacterial cells, some parasitic worms and
HIV infected white blood cells. The report said these mark-
ers may allow such dangerous cells and pathogens to evade
destruction by the human immune system, Imperial College
said Wednesday in a news release.
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Report:12 million new cancer cases in 2007
ATLANTA, -- A report by the American Cancer Society esti-
mates 12 million new cancer cases will be reported worldwide
by the end of this year. An estimated 7.6 million people
will die of cancer in 2007, the report said. The group est-
imates 5.4 million of those cancers and 2.9 million deaths
will occur in economically developed countries while 6.7
million cases and 4.7 million deaths will occur in economic-
ally developing countries, the ACS said Wednesday in a re-
lease. The projections were based on incidence and mortality
data compiled by the International Agency for Research on
Cancer. The three most commonly diagnosed cancers in men are
prostate, lung and colorectal cancer. Among women, they are
breast, colorectal and lung cancer. "The burden of cancer is
increasing in developing countries as deaths from infectious
diseases and childhood mortality decline and more people
live to older ages when cancer most frequently occurs," Am-
erican Cancer Society epidemiologist Ahmedin Jemal said in
a statement. "This cancer burden is also increasing as peo-
ple in the developing countries adopt western lifestyles
such as cigarette smoking, higher consumption of saturated
fat and calorie-dense foods, and reduced physical activity."
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