Publication: Health Tips
Protein may help fight resistant bacteria | |
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HEALTH TIPS - Monday, February 19, 2007
"News That Keeps You Healthy"
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Protein may help fight resistant bacteria
KINGSTON, Ontario, -- Canadian scientists say a new type
of protein they discovered might be useful in developing
treatments for antibiotic-resistant bacteria. Queen's
University researchers in Kingston, Ontario, say their
accomplishment of solving the structure and activity of
the protein -- called YihE or RdoA -- opens possibilities
for new drug development. "Our group is the first to solve
the structure and to begin to understand the function of
this particular protein," said Nancy Martin, who coordin-
ated the study with Zongchao Jia. "It turns out to be a
potentially good target in a wide range of bacteria that
cause infectious diseases." Martin says because of the
increasing number of antibiotic-resistant strains of many
different types of bacteria, such as salmonella, new
approaches to antibiotic therapy are needed. The study by
researchers, who also included Jimin Zheng, Vinay Singh
and Chunhua He, appears in the on-line edition of the
journal Molecular Microbiology.
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Artificial cells may revolutionize therapy
PITTSBURGH, -- U.S. medical researchers predict artificial-
ly created cells might be a new therapeutic approach for
treating diseases in an ever-changing world. Carnegie
Mellon University's Philip LeDuc, an assistant professor
of mechanical and biomedical engineering, posits the ef-
ficacy of using man-made cells to treat diseases without
injecting drugs. "Our proposal is to use naturally avail-
able molecules to create pseudo-cell factories where we
create a super artificial cell capable of targeting and
treating whatever is ailing the body," said LeDuc. "The
human cell is like a bustling metropolis, and we aim to
tap the energy and diversity of the processes in a human
cell to help the body essentially heal itself." LeDuc and
his team want to use the cell's microscopic package of
tightly organized parts to improve medical treatments. For
example, he proposes using the processes in a cell, such
as the membrane, to create an enclosed functioning environ-
ment for a nanofactory. Then, by using other biologically
inspired processes such as molecular-binding and transport,
the pseudo-cell can target, modify and deliver chemicals
that the body needs to function properly. The novel pro-
posal appeared in the January edition of the journal
Nature Nanotechnology.
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Doctors seek to regrow parts of fingers
AUSTIN, Texas, -- Doctors at a Texas military base are
testing a procedure on wounded Iraq veterans that may
allow them to regrow portions of lost fingers. The pro-
cedure involves treatments with a fine powder called
extracellular matrix, which is taken from the bladders
of pigs, the Wall Street Journal said. The substance is
what cells latch on to in mammals to allow them to
divide and grow into tissue. Scientists who developed
the procedure say the substance appears to activate
latent biological processes in humans that encourage
healing and tissue regeneration. They said the processes
are active in human fetuses, which have the ability to
regenerate and grow new parts, but the ability becomes
dormant after birth. "Fetuses can regenerate just about
everything," said Stephen Badylak, a researcher at the
University of Pittsburgh's McGowan Institute for Regen-
erative Medicine. "If those signals are there, how can
we turn them back on?" David Baer, manager of the U.S.
Army unit's bone and soft-tissue program, said the team
does not expect soldiers to regrow whole fingers. "We'd
love to see bone, but we don't know," Baer said. The
hope is for an inch of soft tissue, with blood vessels
and nerves, that soldiers can pinch their thumbs against
and restore some function.
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