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HEALTH TIPS WEEKLY - Thursday, January 31, 2008
"News That Keeps You Healthy"
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DNA mutation causes are studied
STATE COLLEGE, Pa., -- U.S. scientists have conducted the
first genome-wide study comparing the relative importance of
factors that contribute to DNA mutations. The Pennsylvania
State University research team led by Assistant Professor
Kateryna Makova compared factors thought to increase suscep-
tibility to mutations of microsatellites -- variable-length
sequences of recurring DNA subunits. Such mutations are imp-
licated in cancer and more than 40 neurological disorders.
"Our statistical analysis may be useful in predicting which
disease-causing microsatellites are likely to have high
rates of de novo mutations," said Makova. De novo mutations
are those that occur for the first time in a family. The
scientists found mutability increases with repeat number and
microsatellite length -- a finding that had been expected,
Makova said. However, team members said they were surprised
by how strong that relationship was. "Depending on the
number of repeats, the mutability of microsatellites with
the same repeat length varied more than 100 fold," Makova
said.
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Breast size linked to diabetes, study says
TORONTO, -- A Canadian health study suggested a link between
a woman's breast size by age 20 and the development of type
2 diabetes as she matures. A study appearing in the Canadian
Medical Association Journal said an analysis beginning in
1989 found that 1,844 of 92,000 women participating in a
breast-cancer research program developed adult-onset dia-
betes. The study suggested breast size was an independent
factor in diabetics when adjusted for body mass index, the
CTV television network said Tuesday. Researchers said adi-
pose tissue in woman's breast is hormonally sensitive and
likely to influence insulin resistance, leading to diabetes.
The leading scientists in the report cautioned the research
is preliminary and further analysis may determine if breast
reductions decrease the risk of diabetes.
Pancreatic progenitor cells found in mice
BRUSSELS, -- Belgian scientists, in an animal model, have
identified a pancreatic progenitor cell with the capacity
to generate new insulin-producing beta cells. If the finding
by researchers at Vrije University Brussels in mice holds
for humans, the newly found progenitor cells might represent
a target for therapeutic regeneration of beta cells in dia-
betes. In people with type 1 diabetes, blood sugar rises due
to a loss of the insulin-producing pancreatic beta cells.
Insulin is a hormone that helps the body use glucose for
energy. "One of the most interesting characteristics of
these (adult) progenitor cells is that they are almost indi-
stinguishable from embryonic progenitor cells," said Harry
Heimberg at the university's Juvenile Diabetes Research
Foundation Center. Patricia Kilian, regeneration program
director at the center, said the study provides novel in-
sights that might provide therapeutic potential to regen-
erate beta cells in type 1 diabetes. "The most important
challenge now is to extrapolate our findings to patients
with diabetes," Heimberg said.
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Officials question child cold remedies
ATLANTA,-- A U.S. government report said a high number of
emergency room visits by children under 5 years old are
linked to the ingestion of cough and cold medicine. The
Centers for Disease Control and Prevention in its first
estimate on the health effects of common cold and cough med-
icines suggested children sent to emergency rooms for prob-
lems associated with the medicines took the remedies on
their own, The Washington Post said Tuesday. Opponents of
the report said the issue suggests parental monitoring plays
a role in the accidental ingestions but supporters said the
report showed "it's time to pull the plug on the marketing
of these products." The CDC reported at least 1,500 children
2 years and younger had complications from the medication
and the Food and Drug Administration said the ingestions
resulted in at least 123 deaths in 2003-04. The FDA offici-
ally advised against using cough and cold medicines in
children younger than 2 and the pharmaceutical industry
voluntarily took medicines targeted from those children off
the shelves in 2007. The report comes as FDA officials
examine further restrictions on the products as the health
agency said evidence suggests cough and cold medicines are
ineffective on children younger than 6 years old.
Potential new asthma treatment proposed
NEW YORK, -- U.S. scientists have found an enzyme released
by mast cells in the lungs appears to play a key role in
airway constrictions associated with asthma. Weill Cornell
Medical College medical researchers discovered that during
an immune response, mast cells release the enzyme -- called
renin -- that produces angiotensin, a potent constrictor of
the smooth muscle that lines airways. Weill Cornell scien-
tists, in 2005, discovered mast cells in the heart released
renin locally, triggering angiotensin production. "Now,
we've expanded those findings to the lungs, where similar
mechanisms appear to work locally to help trigger constric-
tion in the airway," said study co-author Professor Roberto
Levi. Levi's co-author, Associate Professor Randi Silver,
added: "In the heart and now the lungs, this localized pro-
duction of renin appears to have a profound effect on nearby
tissues, More study is needed, of course, but our finding
suggests that drugs that target renin might prove effective
agents in dampening asthma or other respiratory diseases."
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Stem cells useful in animal stroke models
POCHON, South Korea, -- South Korean and Canadian studies
suggested stroke victims might benefit from transplantation
of human mesenchymal or bone marrow stem cells. In the South
Korean study, researchers transplanted human mesenchymal
stem cells, or hMSCs, into animal stroke models with cere-
bral artery occlusion. The animals were monitored by magnet-
ic resonance imaging at two days, one week, two weeks, six
weeks and 10 weeks after transplant. "Cells started showing
indications of migration as early as one or two weeks foll-
owing transplantation," said lead author Jihwan Song of the
Pochon CHA University College of Medicine. "At 10 weeks, the
majority of the cells were detected in the core of the
infarcted area. "We speculate that the extensive migratory
nature of stem cells and their utilization will provide an
important tool for developing novel stroke therapies," Song
said. In the joint Canadian-Chinese study, bone marrow stro-
mal cells, or BMSCs, were injected into animals 24 hours
following stroke. Researchers found that within seven days
the animals exhibited significant reductions in scar size
and cell death and improvements in neurological function
when compared to controls receiving no BMSCs.
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