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Heart failure enzyme regulator discovered | |
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HEALTH TIPS - Monday, February 26, 2007
"News That Keeps You Healthy"
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Heart failure enzyme regulator discovered
PHILADELPHIA, -- U.S. scientists have discovered an enzyme
important during in fetal heart-cell development also reg-
ulates enlargement of heart cells. Scientists know that in
nearly all forms of heart failure, the heart begins to
express genes that are normally only expressed in the fetal
heart. But it's never been determined what regulates the
development that results in a condition known as cardiac
hypertrophy. Now, investigators at the University of
Pennsylvania's School of Medicine have discovered the
enzyme HDAC regulates cardiac hypertrophy -- a precursor
to many forms of congestive heart failure. "It's as if old
programs are being reactivated in a sick heart," said
senior study author Dr. Jonathan Epstein. "In an adult
heart, stresses such as high blood pressure induce the re-
expression of a fetal gene program." The investigators
found by inhibiting HDAC in adult mice, the fetal-gene
program can be prevented from restarting. The study, which
paves the way for developing new treatments for cardiac
hypertrophy and heart failure, appears in an advanced on-
line publication of the journal Nature Medicine.
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Anti-bacterial dietary supplement created
GHENT, Belgium, -- Belgian scientists say they've developed
a dietary supplement that protects the lives of farm shrimp
from bacterial infections without using antibiotics. The
researchers at Ghent University fed brine shrimp a compound
called poly-ß-hydroxybutyrate, or PHB, that prevented the
shrimp from becoming infected with Vibrio campbellii, an
antibiotic-resistant pathogenic bacteria. "We recently
found that PHB-containing bacteria can also be used to
protect the shrimp from the vibrios (without extracting
the compound from the bacteria) and we are currently test-
ing the potential of such microbes in other animal models,"
said co-investigators Professor Willy Verstraete and Tom
Defoirdt. "Given the fact that PHB can be produced on an
industrial scale for a reasonable price, PHB addition to
animal diets would be an alternative to antibiotics that
is not only effective, but also economically attractive."
The scientists say the finding may make it possible to
protect other organisms from pathogenic bacterial by using
a dietary supplement, thereby replacing antibiotics. The
study is detailed in the journal Environmental Microbiology.
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FDA orders warnings for Xolair
WASHINGTON, -- The U.S. Food and Drug Administration order-
ed Genentech Inc. to add a boxed warning to its asthmatic
drug marketed as Xolair. The FDA said the boxed warning
should emphasize Xolair (omalizumab) might cause anaphyl-
axis, including trouble breathing, chest tightness, dizzi-
ness, fainting, itching and hives and swelling of the
mouth and throat. In addition, FDA ordered Genentech to
revise the Xolair label and provide a medication guide for
patients to strengthen the existing warning for anaphyl-
axis. Xolair was approved in 2003 to treat adults and
adolescents suffering moderate to severe persistent asthma
and who have tested positive for a perennial aeroallergen
and whose symptoms are inadequately controlled with in-
haled steroids. Although anaphylaxis was reported in about
one-in-1,000 patients during clinical trials, the FDA said
continued reports prompted it to issue the Wednesday order.
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