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HEALTH TIPS - Thursday, April 12, 2007
"News That Keeps You Healthy"
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More Health Tips and Health Related Videos on: www.EVTV1.com
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IMPORTANT NOTE: Dear Health Tips readers, starting next week
we will be changing the schedule of Health Tips to mail once
a week on Thursdays. The weekly issue will be longer than
your daily issue so you will still be getting almost as much
news as you do now. Just look for it once a week! We'll see
you next Thursday!
Thanks,
Your Health Tips editor
Revolution in cancer treatment
Cancer treatment could be on the brink of a revolution
following a study showing that it may be possible sig-
nificantly to improve the effectiveness of chemotherapy
drugs without causing side effects. Scientists have con-
ducted a series of pioneering experiments demonstrating
a new way of making tumour cells far more susceptible
to attack with extremely low doses of anti-cancer drugs.
The development offers hope that the gruesome side effects
of chemotherapy, suffered by tens of thousands of cancer
patients, may at some point become a thing of the past.
In addition to making chemotherapy more effective at
eliminating tumour cells from the body, the study suggests
that it is also possible to lower dosage levels to a point
where toxic side effects from the drugs are unlikely to
occur.
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Gene mutation causes infertility in mice
U.S. scientists have discovered a gene mutation that causes
infertility in male mice, giving promise of a similar dis-
covery in infertile men. Cornell University researchers
said their finding marks the first time a dominant mutation
that leads specifically to infertility in a mammal has been
found. "If you consider infertility a disease, you can't
study it like you would other diseases, because the
affected people can't reproduce," said genetics Professor
John Schimenti, director of the university's Center for
Vertebrate Genomics and senior author of the study. "Con-
sequently, we know very little about the genetic causes
of infertility in humans." Researchers randomly induced
mutations in the mouse genome and looked for infertility
in the resulting mice. They analyzed the DNA of the sterile
males and identified the gene that caused the infertility.
Schimenti said mouse models will be critical in distin-
guishing between those DNA sequence changes that are benign
in humans versus those that disrupt sperm or egg production.
The researchers are now engaged in a project to identify
all the genes needed for fertility in mice and apply that
information to the human situation. The research appears in
the journal PLoS Biology.
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Stress causes cancer development
U.S. medical scientists have discovered the stress hormone
epinephrine makes prostate and breast cancer cells resistant
to cell death. Researchers at the Wake Forest University
School of Medicine said they are the first to report that
emotional stress might contribute to the development of
cancer and might also reduce the effectiveness of cancer
treatments. The study, led by Dr. George Kulik, an assistant
professor of cancer biology, was designed to determine
whether there is a direct link between stress hormones and
changes in cancer cells. "Population studies have had con-
tradictory results," said Kulik. "We asked the question:
'If stress is linked to cancer, what is the cellular
mechanism?' There had been no evidence that stress directly
changes cancer cells." Kulik said the study's findings have
several implications for patients and for researchers. "It
may be important for patients who have increased responses
to stress to learn to manage the effects," said Kulik. "And,
the results point to the possibility of developing an inter-
vention to block the effects of epinephrine." The research
is reported on-line in the Journal of Biological Chemistry.
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