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Drug shows promise for Down syndrome | |
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HEALTH TIPS - Friday, March 2, 2007
"News That Keeps You Healthy"
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Drug shows promise for Down syndrome
LOS ANGELES, -- Researchers at California's Stanford
University report a drug known as PTZ can improve the
learning and memory of lab mice with Down syndrome.
After receiving once-daily doses of PTZ, or pentylene-
tetrazole, researchers found the Down syndrome mice
could recognize objects and navigate mazes as well as
normal mice, The Los Angeles Times reported. The im-
provements lasted up to two months after the drug was
discontinued according to a report by the researchers
in the journal Nature Neuroscience. Lead author Craig
C. Garner, a professor at the Stanford School of
Medicine, told the Times that after more preliminary
studies his lab will prepare for conducting human
trials. Down syndrome is the leading cause of mental
retardation. It results from an extra copy of chromo-
some 21.
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Older adults admit plastic surgery
NEW YORK, -- Young U.S. adults might be more embarrassed
than older Americans to admit they've had plastic surgery
than older adults, a study found. The study of 1,000
Americans age 18 years and older, commissioned by the
American Society for Aesthetic Plastic Surgery, found 79
percent of men and 82 percent of women would not be
embarrassed to admit to family and friends they've had
plastic surgery. Twenty-one percent of men and women aged
18 to 24 said they would be self-conscious about revealing
they'd had work done, while 89 percent of those in the 55
to 64 age bracket said they would have no misgivings what-
soever -- up 7 percent from a 2005 survey. Marital status
has little effect on whether a man or a woman would con-
sider having cosmetic surgery, the survey found.
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New treatment for type 1 diabetes studied
ATLANTA, -- Emory University and University of Alberta
scientists say islet cell xenotransplantation presents a
promising near-term diabetes treatment. The researchers
transplanted and engrafted insulin-producing neonatal
porcine islet cells to correct critically low islet cell
supplies created by type 1 diabetes. The scientists from
the Emory Transplant Center, the Yerkes National Primate
Research Center and the University of Alberta col-
laborated to successfully transplant the porcine islet
cells into diabetic rhesus macaque monkeys. The trans-
plantation restored the monkeys' glucose control and
sustained insulin independence, the researchers said.
Islet cell transplantation has been successful in rever-
sing type 1 diabetes in humans, but the limited avail-
ability of islet cells has been problematic. "To meet the
needs of millions of people suffering from type 1 diabetes,
we must find new donor sources to allow large-scale
application of islet cell transplantation in humans," said
Dr. Christian Larsen, director of the Emory Transplant
Center and affiliate scientist at the Yerkes Research
Center. "While there is much work to be done, these studies
suggest the rejection response to porcine islets can be
surmounted."
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