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Drug attacks HIV in a new way | |
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HEALTH TIPS - Tuesday, February 27, 2007
"News That Keeps You Healthy"
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Drug attacks HIV in a new way
POMEZIA, Italy, -- Italian researchers say they've develop-
ed an AIDS drug that attacks the disease in a new way. "The
molecule, MK518, has a wholly new mechanism," Gennaro
Ciliberto, head of a molecular biology research institute
run by drug company Merck, told ANSA. Ciliberto said MK518
and other "integrase inhibitors" may help AIDS patients who
have developed a resistance to other anti-retroviral drugs.
Integrase is an enzyme in HIV that allows the virus to
integrate with body cells, ANSA reported. "If you knock
integrase out of the picture, HIV can't possibly infect any-
one because the virus isn't able to replicate," Ciliberto
told ANSA. ANSA reported Merck expects U.S. Food and Drug
Administration approval for the drug before the end of
2007.
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Caffeine protects elderly hearts
BROOKLYN, N.Y., -- Drinking caffeinated beverages may pro-
tect the elderly against heart disease death, New York
researchers have found. "The protection against death from
heart disease in the elderly afforded by caffeine is likely
due to caffeine's enhancement of blood pressure," said Dr.
John Kassotis, an associate professor of medicine at SUNY
Downstate. The heart-protective effects of caffeine was
only found in patients age 65 and older who were not sev-
erely hypertensive. The researchers from SUNY Downstate
and Brooklyn College used data from the first federal
National Health and Nutrition Examination Survey Epidemi-
ologic Follow-up Study. They found that participants 65
or more years old with higher caffeinated beverage intake
had a lower risk of coronary vascular disease and heart
mortality than did participants with lower intake of
caffeinated beverages.
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Circumcision cuts HIV infection
CHICAGO, -- Circumcision significantly reduces the risk
of acquiring HIV in young African men, a study from the
University of Chicago found. Researchers followed 2,784
young men from Kisumu, Kenya, circumcising half of them.
Forty-seven of the 1,391 uncircumcised men contracted
HIV, compared to 22 of the 1,393 uncircumcised men. "Our
study shows that circumcised men had 53 percent fewer
HIV infections than uncircumcised men," said Robert
Bailey, an epidemiology professor. "We now have very con-
crete evidence that a relatively simple surgical proce-
dure can have a very large impact on HIV." Bailey cau-
tioned that circumcised men might engage in risky
behavior, feeling that they are protected from HIV.
"Circumcision is by no means a natural condom," said
Bailey. "We do know that some circumcised men become
infected with HIV. But we did find that the circumcised
men in our study did not increase their risk behaviors
after circumcision. In fact, all men in the trial
increased their condom use and reduced their number of
sexual partners." The study appears in the Feb. 24 issue
of The Lancet.
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