Publication: Diabetes Update The Numer One Priority | |
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Diabetic Digest - Wednesday, June 20, 2007
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News, updates and help from and for the diabetic community.
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Readers:
A week ago I had an appointment to visit my doctor. Every-
thing went well and I received my results for the A1C
blood test a few days later. My blood-sugar average (for
the passed three months) was 129 and my A1C reading was a
5.8... which is perfect.
I don't mean to toot my own horn, but my health is my
number one priority. I get nervous when it comes time for
me to pay my doctor a visit. So many problems occur with
those that have diabetes and don't take care of themselves.
I just want to avoid any problems or complications with
this manageable illness. I want to enjoy all that I can
without the burdon of illness.
I take care of myself and that leaves me more time than I
know what to do with. I guess what I'm trying to say is...
take care of yourself and your time will be filled with
those things that make life worth living.
Have a great day.
Regards,
Steve
Diabetic Update Newsletter
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Diabetes Drug May Help Obese People Eat Less
NEW YORK (Reuters Health) - Obese subjects ate nearly 1,000
fewer calories per day when they injected pramlintide, a
drug approved for the treatment of insulin-dependent
diabetes, before every meal, a new study shows.
The subjects were also less likely to binge eat and ate
less when faced with "fast-food challenges" of deep-dish
pizza, sugary sodas and ice cream.
Pramlintide is a synthetic version of the human hormone
amylin, which is secreted by the pancreas along with
insulin after meals. Amylin is referred to as a "satiety"
hormone, meaning it signals a feeling of fullness to let
the body know it is time to stop eating.
San Diego-based Amylin Pharmaceuticals makes pramlintide,
which is sold under the trade name Symlin. In previous
studies, the company demonstrated that people taking Symlin
for 1 year lost 8 percent of their body weight. The current
study was designed to evaluate how the drug contributes to
weight loss.
Dr. Christian Weyer of Amylin and his colleagues randomly
assigned 88 obese subjects self-injection with pramlintide
or placebo before each meal for 6 weeks. During the course
of the study, participants underwent three "fast-food
challenges."
By the third day of the study, the subjects on pramlintide
were consuming about 750 fewer calories a day than those on
placebo and 990 calories a day less than before they began
taking the drug. At day 43, those on pramlintide were
eating about 500 fewer calories than those on placebo.
While the pramlintide-placebo calorie intake difference
shrank as the patients on the drug lost weight, it remained
"robust," the researchers note, which is "noteworthy" given
that people typically start feeling hungrier after they
lose a significant amount of weight.
The subjects on pramlintide also ate smaller portions and
consumed less during the fast food challenges. The
pramlintide group ate 385 fewer calories on the challenge
at 44 days compared with the initial challenge on day 2,
while the corresponding number for the placebo group was
109 fewer calories.
By day 44, the pramlintide group lost an average of 2
percent of their total body weight, compared with an
average gain of 0.11 percent for those on placebo.
While peptide hormones like pramlintide have been shown to
induce nausea, Weyer and his team point out, they used a
low dose in the current study, and study participants
taking the drug were not significantly more likely to feel
nauseous than those on placebo.
Weyer told Reuters Health that his group is now evaluating
a combination of pramlintide and leptin -- another satiety
hormone -- or treating obesity. Studies in animals have
found the combination produces a stronger effect than
either hormone alone. The researcher said results of human
studies of the hormone combination are expected this year.
SOURCE: American Journal of Physiology, Endocrinology and
Metabolism, July 2007.
Copyright 2007 Reuters Limited.
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Diabetic Recipe
Roasted Red Pepper Dip
(makes about 2 1/2 cups, 600 ml)
2 large red bell peppers, about 1 pound (480 g) total
1 large red onion, 8 ounces (240 g), peeled and sliced
2 large garlic cloves, peeled
1 cup (240 ml) plain nonfat yogurt
2 tablespoons (30 ml) minced fresh parsley
1/4 teaspoon (1.25 ml) hot pepper sauce
salt (optional) and freshly ground pepper to taste
1. Preheat the broiler. Cut peppers in half lengthwise,
discarding seeds and membranes. Place the peppers,
cut side down, on a foil-lined baking sheet.
2. Surround with onion and garlic. Broil for 10 minutes or
until peppers are blackened. Immediately place peppers
in self-sealing plastic bag. Seal and let stand for
15 minutes. Rinse peppers under running cold water,
slipping off the peel.
3. Place peeled peppers, onion, and garlic in a food
process or blender. Process until finely chopped.
Transfer mixture to a bowl and fold in remaining
ingredients. Cover and chill until ready to serve.
(May be made the day before.)
Per 2-tablespoon (30 ml) serving: 19 calories (4% calories
from fat), 1 g protein, trace total fat (0 saturated fat),
4 g carbohydrate, 1 g dietary fiber, trace cholesterol,
10 mg sodium
Exchanges: free (for 2-tablespoon portion; if eating more,
it becomes 1 vegetable)
Copyright Diabetic-Lifestyle
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GopherCentral's Question of the Week
Should Illegal Aliens receive government subsidized health
benefits in the US?
Please take a moment to share your opinion, visit:
Question of the Week
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Copyright 2007 by NextEra Media. All rights reserved.
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