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Chemo drug may hike tumor immunity | |
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HEALTH TIPS - Wednesday, February 21, 2007
"News That Keeps You Healthy"
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Scientists identify yeast protein
BALTIMORE, -- U.S. scientists studying how yeast makes
cholesterol have identified a protein whose human counter-
part controls cholesterol production and metabolism. The
collaborative study was conducted by investigators at
Johns Hopkins University School of Medicine, Vanderbilt
University, Indiana University and the Eli Lilly Co. "Dap1
controls the activity of a clinically important class of
enzymes required for cholesterol synthesis and drug metab-
olism," said Johns Hopkins Assistant Professor Peter
Espenshade. "We're excited because, although we originally
identified this protein in yeast, humans not only have the
same protein, but it works the same way." The search for
Dap1 began with the hunt for factors that influence the
actions of a large family of enzymes called cytochrome
P450. Those enzymes control many life-sustaining chemical
reactions in humans and other animals. "Understanding the
molecular underpinnings of so-called pharmacogenetic
variation will have a big impact on the future of
medicine," Espenshade said. The research appears in the
February issue of the journal Cell Metabolism.
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Chemo drug may hike tumor immunity
NEW YORK, -- U.S. scientists have discovered a chemotherapy
drug might enhance patients' immunity to tumors, helping
them to more effectively fight the disease. Rockefeller
University researchers have found that a chemotherapy drug
called bortezomib can kill multiple myeloma cells -- cancer
in immune cells in bone marrow -- in culture in such a way
that it elicits a response by memory and killer T cells.
Until recently it's been thought radiation therapy and
various forms of chemotherapy were separate but equal
treatments. Now, however, new research is beginning to
show it's not just killing the cancer cells that matters
-- it's also important as to how they are killed. A study
by Associate Rockefeller University Professor Madhav
Dhodapkar, postgraduate fellow Radek Spisek and col-
leagues shows bortezomib kills tumor cells in such a way
that it might allow the immune system to recognize them.
The study is detailed online in the journal Blood.
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New drugs show promise for prostate cancer
LOS ANGELES, -- U.S. oncologists say a new class of target-
ed anti-cancer drugs shows promise in prolonging the lives
of patients with recurrent prostate cancer. The research by
scientists at Cedars-Sinai Medical Center in Los Angeles
show a molecular targeted compound called pertuzumab blocks
the human epidermal growth factor receptor family by bind-
ing to and inhibiting the function of HER2 receptors,
interrupting a key pathway that leads to cancer growth.
"Advanced prostate cancer is difficult to treat and the
drug therapies currently available to these patients have
not been very effective, especially in patients whose
disease has progressed after chemotherapy treatment," said
Dr. David Agus, principal investigator of the study. Agus
said the theory is that by significantly slowing pro-
gression of the cancer, patients will experience a good
quality of life for a longer period of time. "Ultimately,
we hope drugs like pertuzumab will help us reach the point
where cancer can be viewed as a lifetime disease to be
managed much like AIDS is looked at now," he added. "This
would be major shift from the current paradigm for cancer
treatment, and is a promising area of research." The
study appears in the Journal of Clinical Oncology.
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