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A breath might soon foretell disease | |
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HEALTH TIPS WEEKLY - Thursday, February 21, 2008
"News That Keeps You Healthy"
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Neuromuscular disease study gives new info
AUGUSTA, -- U.S. scientists have discovered if a muscle cell
fails to produce the protein beta-catenin, its neuron doe-
sn't develop or function properly. Medical College of Geor-
gia researchers said their finding provides some of the
first proof that in vertebrates retrograde communication --
from the target cell back to the neuron -- is essential.
"Previously, we thought signals flow mainly from neuron to
muscle. This shows they can be produced from muscle," said
Dr. Lin Mei, the Medical College of Georgia's chief of deve-
lopmental neurobiology. "This is some of the first clear
genetic evidence that when you disturb something in the
muscle, you have a nerve problem." Mei's team knocked out
beta-catenin in the muscle cells of a developing mouse. As a
result, nerve terminals were misaligned. Release of neuro-
transmitters was impaired and the mice died prematurely.
"Theoretically the finding is very important in that it
supports the retrograde hypothesis," said Mei. "We believe
there is a retrograde signal downstream of beta-catenin or
regulated by beta-catenin. If you don't have beta-catenin in
the muscle, that signal may be missing and motor neurons are
not happy." The research is detailed online in the journal
Nature Neuroscience.
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A breath might soon foretell disease
BOULDER, Colo., -- U.S. scientists have created a technique
that analyzes a person's breath to detect trace compounds
that might provide early warning signs of disease. A team
led by Jun Ye, a physicist at JILA -- a joint facility of
the National Institute of Standards and Technology and the
University of Colorado at Boulder -- demonstrated the opti-
cal technique for simultaneously identifying tiny amounts of
a broad range of molecules in the breath, potentially enab-
ling a fast, low-cost screening tool for disease. "It is
exciting to imagine the potential of analyzing all major
biomarkers in one's breath at once," said Ye. "For example,
nitric oxide can indicate asthma but it also appears in
breath with many other lung diseases, including chronic
obstructive pulmonary disease, cystic fibrosis and bronch-
iectasis. "However," he added, "if we simultaneously moni-
tor nitric oxide, carbon monoxide, hydro-peroxide, nitrites,
nitrates, pentane and ethane, all important biomarkers for
asthma, we can be much more certain for a definitive diag-
nosis of this important disease." The research is reported
in the journal Optics Express.
New craniosynostosis surgery is effective
COLUMBIA, Mo., -- U.S. scientists have found a minimally
invasive surgical technique to treat craniosynostosis --
the premature fusion of an infant's skull -- is effective.
Surgeons have used one of two procedures to correct the pro-
blem. One procedure was to make an incision from ear to ear,
strip back the infant's scalp and reshape the skull by
breaking the fused bones. The other procedure required a
small incision near the point of the fused skull plates.
In the new study, University of Missouri School of Medicine
researchers found the minimally invasive technique is just
as effective and results in a quicker recovery time than the
old technique. With craniosynostosis, two or more of the
skull plates fuse prematurely, restricting growth in the
head for the brain. "Instead of exposing the skull as surg-
eons do with the old technique, we are able to make two
small incisions and remove a small strip of bone," said
Assistant Professor Dr. Usiakimi Igbaseimokumo, who said the
procedure is not only successful in correcting the problem
but is also as effective than the older procedure in the
long term. Igbaseimokumo presented the findings during a
recent meeting of the International Society of Pediatric
Neurosurgeons.
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Nightime light linked to cancer
HAIFA, Israel, -- An Israeli study said women who live in
well-lighted neighborhoods are more likely to develop breast
cancer than those who live in darker areas. The findings of
the study, which combined satellite images with local breast
cancer statistics, support the theory that too much light at
night raises the risk of breast cancer by interfering with
the production of melatonin, The Washington Post reported
Wednesday. The findings are published in the online version
of the journal Chronobiology International. Lead author Itai
Kloog of the University of Haifa said satellite data showing
how much light was emitted from neighborhoods throughout
Israel was overlaid with local statistics on cases of breast
cancer. The researchers found the breast cancer rate in
areas with average night lighting to be 37 percent higher
than in communities with the lowest amount of light. Epid-
emiological studies of nurses, flight attendants and others
who work at night have found breast cancer rates 60 percent
above normal and an arm of the World Health Organization
recently decided to classify shift work as a "probable
carcinogen," the newspaper said.
Music helps stroke patients recover
HELSINKI, Finland, -- Researchers in Finland found that
when stroke patients listen to music for a couple of hours
a day, their verbal memory and focused attention recover
better. The study, published in the journal Brain, also said
stroke patients who listened to music had a more positive
mood than patients who did not listen to anything or who
listened to audio books. First author Teppo Sarkamo, a doc-
toral student at the University of Helsinki and at the
Helsinki Brain Research Centre, focused on patients who had
suffered a stroke. The researchers recruited 60 patients to
the single-blind, randomized, controlled trial from March
2004 to May 2006. They worked with the patients as soon as
possible after they had been admitted to the hospital. Most
of the stroke patients had problems with movement and with
cognitive processes, such as attention and memory. Some
were assigned to listening to music -- pop, classical, jazz
or folk -- some to audio books and one group was the cont-
rol. All received standard stroke rehabilitation. Three
months after the stroke, verbal memory improved by 60 per-
cent in music listeners, 18 percent in audio book listeners
and 29 percent in the control group, the study said.
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Biomarkers may guide lung cancer treatment
LOS ANGELES, -- U.S. scientists have discovered biomarkers
that predict which patients with advanced non-small cell
lung cancer will better respond to specific treatments. The
researchers at UCLA's Jonsson Comprehensive Cancer Center
said the biomarkers predict which such patients will respond
to a combination treatment of the anti-inflammatory drug
Celebrex and the growth factor receptor blocker Tarceva. The
scientists said their finding might help oncologists person-
alize treatment, prescribing drugs they know patients will
respond to and sparing them from therapies that won't work.
Dr. Steven Dubinett, senior author of the study, said the
findings, if confirmed, would provide personalized drug com-
bos as an alternative therapy. "We need good predictors of
response to targeted therapy in lung cancer so individual
patients receive the specific therapy that targets the part-
icular molecular abnormalities of their tumors," said
Dubinett. The research appears in the Journal of Thoracic
Oncology.
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